When arthritis pain strikes, you want relief fast, but you also want it to last so you can get back to normal… whatever your normal is. Try Tylenol Arthritis Pain. Tylenol Arthritis Pain products use a patented bi-layer caplet for fast plus long lasting relief of arthritis pain for up to 8 hours. The first layer dissolves quickly to relieve pain fast. The second layer is time-released to provide extended relief that lasts all work day (up to 8 hours of relief).